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Estradot - the benefits and how to use it

Estradot is a form of oestrogen replacement therapy. It is a transdermal patch, meaning it delivers oestrogen through the skin rather than through the mouth. It is used as part of a Hormone Replacement therapy plan (HRT).

If you are considering Estradot as part of your HRT plan, here is what you need to know about how to use it, its benefits, and possible side effects.

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Medically reviewed by Dr Zahra Khan

MBBS, MSc

iconUpdated on 1st August 2025

What is Estradot?

Estradot is a type of hormone replacement therapy (HRT) used to relieve symptoms of menopause. It is an oestrogen-only patch that delivers a steady, low dose of estradiol, a body identical form of oestrogen, through the skin and into the bloodstream.

Estradot works by restoring oestrogen levels in the body. It is a systemic form of HRT, which means that it circulates throughout the body. This helps relieve widespread symptoms of menopause.

It can be used whether or not you've had a hysterectomy, it’s prescribed on its own if you don’t have a womb, or alongside progesterone if you do.

Estradot is a popular choice among transdermal HRT options due to its:

  • Consistent hormone delivery: As a patch, Estradot provides steady hormone levels throughout the day and night, reducing the hormonal fluctuations that can occur with oral HRT.
  • Lower clotting risk: Because it is absorbed through the skin (rather than the digestive system), Estradot bypasses the liver, which lowers the risk of blood clots and stroke compared to oral oestrogen.
  • Small, discreet design: The patch is smaller than a postage stamp and designed to adhere well, even during showers and moderate exercise.
  • Dose flexibility: Estradot is available in a wide range of strengths (25 mcg, 50mcg, 75mcg and 100mcg), so the dose can be tailored to your symptoms and needs.
  • Good adhesive: Many Estradot users report that this patch sticks very well and therefore they do not have to worry about it falling off during exercise.

Learn more about your symptoms

Frequently asked questions about Estradot patches

How to use Estradot

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Everything you need to know to safely use Estradot patches

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The symptoms Estradot can help with

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Dr Zahra Khan

Estradot can help to relieve a wide range of symptoms related to hormones changes. There are over 40 symptoms of menopause, but some of the most common ones are listed here.

1 Hot flushes and night sweats
2 Low mood, anxiety, or irritability
3 Sleep issues and fatigue
4 Brain fog and difficulty concentrating
5 Reduced libido
6 Vaginal dryness
7 Bone protection when started around the time of menopause