Is Sandrena a good HRT option?

Yes. It’s well-tolerated, effective, and especially useful for those who prefer a non-oral form of HRT.

Can Sandrena cause weight gain?

There is no strong evidence that Sandrena causes weight gain. Some women may feel bloated or notice body changes due to fluid retention or improved appetite as symptoms ease. Talk to your clinician if you have concerns—adjustments can often be made.

Where’s the best place to apply Sandrena?

Outer thigh, buttock, or lower abdomen. Avoid the breasts, face, or broken skin.

How quickly does Sandrena work?

Most women begin to notice improvements within 2–4 weeks of consistent use, though it may take up to 3 months to feel the full benefits⁴.

What if I forget a dose?

Apply it as soon as you remember. If it’s nearly time for your next dose, skip the missed one, don’t double up.

Sandrena

Learn what Sandrena is, its benefits and how to use it safely

Medically reviewed by Dr Zahra Khan

MBBS, Msc

Updated on 1st August 2025

What is Sandrena Gel?

Sandrena is a transdermal oestrogen-only gel used as part of hormone replacement therapy (HRT). It contains estradiol, a body-identical form of oestrogen, to replace the hormone your body gradually stops producing during perimenopause and menopause.

It comes in pre-measured 0.5mg or 1mg sachets. The dose is tailored to your needs based on symptoms and treatment goals.

If you still have your womb, Sandrena will be prescribed alongside progesterone to protect the lining of your womb. This may be in the form of a tablet or a Mirena coil.

Why choose Sandrena?

Sandrena is part of the transdermal (through the skin) group of HRT options, which means the oestrogen is absorbed directly into the bloodstream, bypassing the liver. This offers several advantages:

Lower risk of blood clots than oral HRT¹
Gentler on the stomach and liver, especially if you have digestive issues
Flexible dosing with easy-to-adjust sachets
Quick-drying, low-volume gel that some women find more convenient than pump-based gels like Oestrogel
Stable oestrogen levels, which may improve mood and reduce hormone fluctuations²

Sandrena is especially suitable if:

You prefer not to take tablets
You’ve experienced side effects with oral HRT
You’re at increased risk of clotting or cardiovascular problems
You want a discreet and adaptable option that fits into your daily routine

How to use Sandrena

Instructions for use

Everything you need to know to safely use Sandrena gel

1 Hot flushes and night sweats

2 Low mood, anxiety, or irritability

3 Sleep issues and fatigue

4 Brain fog and difficulty concentrating

5 Reduced libido

6 Vaginal dryness

7 Bone protection when started around the time of menopause³

This page is provided for reference purposes only. Always follow the advice and guidance of your prescribing doctor regarding your medication and prescriptions. Do not make any changes to your medication regimen without consulting your healthcare provider.

Sandrena

What is Sandrena Gel?

Why choose Sandrena?

How to use Sandrena

Benefits of Sandrena Gel

Frequently asked questions